Preheat your oven to 350°F. In a large skillet, add the olive oil and brown the ground beef on medium-high heat for 5 minutes
Pour in the crushed tomatoes and season with garlic powder, dried oregano, salt, and black pepper. Stir well to combine then simmer for 10 minutes on low heat.
Meanwhile, boil the Penne al dente according to the directions on the package.
Drain the pasta, then pour half of it into a baking dish.