Preheat your oven to 350°F. Lightly coat a 9×13-inch baking dish with non-stick cooking spray.
Bring a large pot of salted water to a boil. Cook the lasagna noodles as per the package instructions until al dente. Once done, drain and set aside.
In a large skillet, heat the olive oil over MEDIUM heat. Add the diced onion and minced garlic, sautéing until the onion is translucent and fragrant, about 3 minutes. Add the ground turkey, breaking it apart with a spoon, and cook until browned, about 5 minutes.
Add to the skillet with the turkey the tomato sauce, tomato paste, dried oregano, dried basil, sugar, kosher salt, black pepper, and red pepper flakes. Stir. Simmer on LOW for 5 minutes to meld the flavors. Taste and adjust seasoning as needed.