Preheat your oven to 350°F. In a large skillet add the olive oil and brown the ground beef on medium-high heat for 5 minutes.
Pour in the crushed tomatoes and season with garlic powder, dried oregano salt, and black pepper. Stir well to combine then simmer for 10 minutes on low heat.
Meanwhile, boil the Penne al dente according to the directions on the package.
Drain the pasta, then pour half of the pasta into a baking dish.
Layer half of the meat sauce over the pasta and top with half of the mozzarella cheese. Lay half of the pepperonis on top then add the remaining pasta, meat sauce, cheese, and pepperoni.
Sprinkle the Parmesan on top and cover the baking dish with foil. Bake in the preheated oven for 15 minutes until bubbly and brown.
Remove the pizza pasta casserole from the oven and let cool for 5 minutes before serving. Garnish with fresh basil leaves and additional grated parmesan cheese. Enjoy!